Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

Regulatory circuits of inflammatory cytokines at interface (CROSBI ID 485442)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Rukavina, Daniel Regulatory circuits of inflammatory cytokines at interface // Abstract book / Kurpisz Maciej (ur.). Poznań: -, 2000. str. --x

Podaci o odgovornosti

Rukavina, Daniel

engleski

Regulatory circuits of inflammatory cytokines at interface

The current dogma in reproductive immunology is that in pregnancy potentially harmful TH1 (cell-mediated) responses are suppressed whereas TH2 (antibody-mediated) responses are normal. However, there are data showing that this is an over-simplification and that while adaptive immune responses are suppressed in pregnancy innate immune (inflammatory) responses are activated. Increased levels of interleukin (IL)-2, 12 and interferon -  (INF) have been reported to be associated with embryonal resorption and abortion. Cytokine network at the interface is a unique. Pleiotropy and redundancy of IL-2 and IL-15 at this place is of great physiological significance. These cytokines together with IL-12 and IL-18 regulate cytolytic machinery (perforin expression) of both decidual cytotoxic T lymphocytes (CTL) and NK (dNK) cells which are predominant lymphocyte population at the interface. The pregnant uterus harbors the highest concentration of perforin known to occur in any physiological or pathological condition. This cytolytic molecule might therefore subserve an immune surveillance function in protecting both mother and fetus.

TH1; TH2; Cytokines; IL-2; IL-15; CTL; dNK cells; Perforin; IL-18

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

--x.

2000.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Abstract book

Kurpisz Maciej

Poznań: -

Podaci o skupu

The 3rd Congress of ESRADI

pozvano predavanje

19.11.2000-21.11.2000

Poznań, Poljska

Povezanost rada

Temeljne medicinske znanosti