Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Physiological role(s) of IL-15 and IL-18 at the maternal-fetal (M-F) interface. Session: Cytokine regulation in pregnancy (CROSBI ID 485465)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Rukavina, Daniel ; Bogović, Tatjana ; Sotošek, Vlatka ; Laškarin, Gordana ; Štrbo, Nataša ; Juretić, Koraljka ; Ćupurdija, Kristijan ; Tsuji, Yoshiyuki ; Kojama, Koji Physiological role(s) of IL-15 and IL-18 at the maternal-fetal (M-F) interface. Session: Cytokine regulation in pregnancy // American journal of reproductive immunology. 2002. str. 139-140

Podaci o odgovornosti

Rukavina, Daniel ; Bogović, Tatjana ; Sotošek, Vlatka ; Laškarin, Gordana ; Štrbo, Nataša ; Juretić, Koraljka ; Ćupurdija, Kristijan ; Tsuji, Yoshiyuki ; Kojama, Koji

engleski

Physiological role(s) of IL-15 and IL-18 at the maternal-fetal (M-F) interface. Session: Cytokine regulation in pregnancy

It is almost dogma that IL-2 is not expressed at the M-F interface during normal pregnancy. However, recent results by ours and others clearly showed that IL-15 -Th1 type cytokine which shares many similarities with IL-2 is expressed at the interface. IL-15 can affect cytolytic activity of maternal decidual lymphocytes which heavily infiltrate maternal decidua during the first trimester pregnancy. These cells are in a direct contact with trophoblastic cells. IL-18 is a recently discovered Th1 type cytokine with many interesting functions. The aim is to examine IL-18 distribution at the interface and its potential in upregulating peripheral blood (PB) and decidual lymphocytes (DL) cytotoxicity. Th1 activated lymphocytes are LAK cells and they can kill by both Perforin and Fas pathways in non MHC restricted manner. PBL and DL were obtained from elective pregnancy termination of pregnancy. IL-18 and IL-18R expression was detected by flow cytometry and immunohistology and cytolytic potential by cytotoxicity against K-562 (NK sensitive) and P815 (NK resistant) cell lines. IL-18 positive cells were found in the suspension of Decidual adherent cells and IL-18 R expressions at the trophoblastic cells of villi. Both IL-15 and IL-18 are increasing cytolytic potential of PBL and DL against NK sensitive cell line. Decidual lymphocytes are activated cells with the potential of killing NK resistant but LAK sensitive lines and this is mediated by both perforin and Fas pathways. Physiological and pathophysiological role(s) of cytolytic pathways and Th1 cytokines (IL-15 and IL-18) at the interface will be discussed.

decidua; IL-15; IL-18

Germany Conference venue: 'Neue Weimarhalle'.

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

139-140.

2002.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

American journal of reproductive immunology

1046-7408

Podaci o skupu

Congress of the Alps Adria Society for Immunology of Reproduction (8 ; 2002)

pozvano predavanje

07.09.2002-10.09.2002

Weimar, Njemačka

Povezanost rada

Temeljne medicinske znanosti

Indeksiranost