engleski

The influence of the tannic acid on the expression of the connexins 45 in a rat kidney damaged by the chronic hyperglycemia

The aim was to demonstrate the potential negative effect of the tannic acid on the expression of connexin 45 in rat kidney damaged by the chronic hyperglycemia, due to a need for critical assessment of the positive effects of the use of tannic acid in the treatment of many diseases. Twelve male Wistar rats were used in the trial over a period of twenty weeks. The rats were divided into three groups of four rats. The first group of rats was receiving a drinkin g water (control group, C). The second group was receiving 30% w/v sucrose solution in drinking water (sucrose group, Suc), while the third group received 30% w/v sucrose solution and 0.1% w/v tannic acid in drinking water for 20 weeks (sucrose+tannic acid group, Suc+TA). Pathohistologically, we observed damage of the kidneys caused by the hyperglycemia, while damage was more expressed in the Suc/TA group. Analysis of the microphotographs showed that high sucrose treatment caused reduced expression of con nexin 45 in the proximal tubules of the kidney, and the addition of the tannic acid made the reduction statistically significant (p <0.05). Based on the results, we concluded that the tannic acid in combination with the chronic hyperglycemia, in the dosage of 0.1% in drinking water decreases the expression of the connexin 45 in the proximal tubules of the rat kidney.

diabetes mellitus type 2 ; tannic acid ; connexins ; chronic sucrose treatment

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