Highly fluorescent biologically active iminocoumarines with interesting spectroscopic properties (CROSBI ID 658571)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Cindrić, Maja ; Perin, Nataša ; Starčević, Kristina ; Maurić, Maja ; Liekens, Sandra ; Hranjec, Marijana
engleski
Highly fluorescent biologically active iminocoumarines with interesting spectroscopic properties
The coumarin derivatives have been one of the most widely studied classes of fluorescent dyes and probably one of the most frequently used fluorescent compounds. Fluorescent coumarin derivatives have been widely used in many applications from cell biology, medical analysis, lasers, sensors, to the advanced photophysical systems [1]. This work presents the synthesis of iminocoumarine derivatives as a potential biologically active agents. Their molecular structure incorporate a push-pull functionality, the N, N-dialkylamino group at the 7-position is an electron donor, while an electron withdrawing group, such as benzimidazole, benzothiazole and imidazopyridine fragment at the 3-position, enhances the fluorescence efficiency. The spectroscopic properties of these compounds were evaluated in several polar and non-polar organic solvents. pH titrations were carried out to explore their potential as chemosensors and pH probes. Antioxidative potency has been evaluated by in vitro spectrophotometric assays and antitumor activity in vitro was tested on three human tumour cell lines [2, 3].
iminocoumarines, pH titrations, chemosensors, antioxidative activity, antitumor activity
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Podaci o prilogu
50-50.
2018.
objavljeno
Podaci o matičnoj publikaciji
Podaci o skupu
Central European Conference on Photochemistry (CECP 2018)
poster
04.02.2018-08.02.2018
Bad Hofgastein, Austrija