engleski

Concentration of trace elements in the hair of patients diagnosed with schizophrenia compared to patients with major depressive disorder ; A cross sectional study in Croatia

Differing concentrations of trace elements (TE) may play a role in the pathogenesis of schizophrenia and major depressive disorder (MDD). The aim of this study was to compare such differences. This cross- sectional study was conducted in 2015 at the psychiatric hospitals Sveti Ivan and Vrapče in Zagreb, Croatia, on a consecutive sample of 75 patients diagnosed with schizophrenia (ICD-10 F20) and 32 patients with MDD without psychotic symptoms (ICD-10 F33). The analysis showed the concentration of 34 TE. The samples were analysed with inductively coupled plasma mass spectrometry (ICP- MS). After the adjustment of sex and age, results showed a significantly lower TE concentration in the samples taken from patients with schizophrenia, particularly in the concentration of silicon 100%, calcium 96% and sodium 92%.

schizophrenia, patients, trace elements, concentration, hair, major depressive disorder, cross sectional study, Croatia

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