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Genetic diversity of human metapneumovirus in hospitalized children with acute respiratory infections in Croatia (CROSBI ID 249120)

Prilog u časopisu | izvorni znanstveni rad

Jagušić, Maja ; Slović, Anamarija ; Ljubin- Sternak, Sunčanica ; Mlinarić-Galinović, Gordana ; Forčić, Dubravko Genetic diversity of human metapneumovirus in hospitalized children with acute respiratory infections in Croatia // Journal of medical virology, 89 (2017), 11; 1885-1893. doi: 10.1002/jmv.24884

Podaci o odgovornosti

Jagušić, Maja ; Slović, Anamarija ; Ljubin- Sternak, Sunčanica ; Mlinarić-Galinović, Gordana ; Forčić, Dubravko

engleski

Genetic diversity of human metapneumovirus in hospitalized children with acute respiratory infections in Croatia

Human metapneumovirus (HMPV) is recognized as a global and frequent cause of acute respiratory tract infections among people of all ages. The objectives of this study were molecular epidemiology and evolutionary analysis of HMPV strains which produced moderate and severe acute respiratory tract infections in children in Croatia during four consecutive seasons (2011-2014). A total of 117 HMPV-positive samples collected from hospitalized pediatric patients presenting with acute respiratory tract infections and tested by direct immunofluorescence assay were first analyzed by amplifying a part of the F gene. Sixteen samples were further analyzed based on complete F, G, and SH gene sequences. HMPV genome was identified in 92 of 117 samples (78%) and the circulation of multiple lineages of HMPV was confirmed. In 2011, 2012, and 2014, subgroups A2 and B2 co-circulated, while B1 gained prevalence in 2013 and 2014. The study established the presence of a novel subcluster A2c in Croatia. This subcluster has only recently been detected in East and Southeast Asia. This study provides new insights into epidemiology and genetic diversity of HMPV in this part of Europe.

human metapneumovirus ; fusion protein ; glycoproteins ; genetic variability, epidemiology

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Podaci o izdanju

89 (11)

2017.

1885-1893

objavljeno

0146-6615

10.1002/jmv.24884

Povezanost rada

nije evidentirano

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