IgG avidity: an important serologic marker for the diagnosis of tick-borne encephalitis virus infection (CROSBI ID 249158)
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Podaci o odgovornosti
Vilibić-Čavlek, Tatjana ; Barbić, Ljubo ; Stevanović, Vladimir ; Petrović, Goranka ; Mlinarić-Galinović, Gordana
engleski
IgG avidity: an important serologic marker for the diagnosis of tick-borne encephalitis virus infection
A total of 52 serum samples from patients with symptoms suggestive of tick-borne encephalitis virus (TBEV) infection and positive IgM and/or IgG antibodies were tested for IgG avidity. Acute/recent TBEV infection was confirmed by low/borderline avidity index (AI) in 94.8% IgM positive/IgG positive samples, while in 5.2% high AI was found indicating persisting IgM antibodies. Majority of IgM negative/IgG positive samples (78.6%) showed high AI consistent with past TBEV infection. However, in 21.3% patients without measurable IgM antibodies current/recent infection was confirmed by AI. IgG avidity represents an additional serologic marker that improves diagnosis of TBEV, especially in cases of atypical antibody response.
Tick-borne encephalitis virus ; IgG avidity
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Podaci o izdanju
Povezanost rada
Javno zdravstvo i zdravstvena zaštita, Veterinarska medicina