Exiting mamalian cells by Legionella pneumophila: Temporal pore formation-mediated cytolysis (CROSBI ID 485701)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Radulić, Marina ; Šuša, Milorad ; Abu Kwaik, Yousef ; Dorić, Miljenko
engleski
Exiting mamalian cells by Legionella pneumophila: Temporal pore formation-mediated cytolysis
Legionella pneumophila can infect and multiply intracellularly in both human phagocytic cells and protozoa, but it also persist in the environment as a free-living microbe. L. pneumophila is the most common Legionella species that cause Legionnaire's disease, a serious and often fatal form of pneumonia in humans. In our experiment A/J mice which are susceptible to replicative L. pneumophila lung infection, were inoculated intratracheally with virulent strain AA100 and rib mutant (release of intracellular bacteria) of L. pneumophila. We have showed that, similar to the protozoan host, the induction of necrosis of alveolar epithelium and lysis of inflammatory cells is mediated by pore-forming toxin. However, we aslo conclude that pore forming activity of L. pneumohila is not required for intracellular replication.
mammalian cell; Legionella pneumophila
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nije evidentirano
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nije evidentirano
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Podaci o prilogu
82-x.
2002.
objavljeno
Podaci o matičnoj publikaciji
Power of microbes in industry and environment
Mrša, Vladimir ; Hajsig, Danko
Zagreb: Prehrambeno-biotehnološki fakultet Sveučilišta u Zagrebu
Podaci o skupu
Croatian, Hungarian and Slovenian Symposium on Industrial Microbiology and Microbial Ecology: Power of microbes in industry and environment
poster
07.06.2002-09.06.2002
Opatija, Hrvatska