engleski

A randomized, double blind, parallel-group, duration-finding study of oral terbinafine and open-label, high-dose griseofulvin in children with tinea capitis due to Microsporum species

Tinea capitis, a common clinical pattern of dermatophyte infection in children is bedoming a public health hazard in some countries. Several studie have reported terbinafine to be a save and well tolerated fungicidal drug for the treatment of this infection. However, the optimal treatment duration for each use in the treatment of tinea capitis caused by Microsporum species has not yet been determined.To establish the optimal duration for terbinafine treatment to bring about complete cure of tinea capitis due to Microsporum infection in a large paediatric population, and (ii) to obtain information of the maximum therapeutic effect of the existing therapy. This parallel group doubl.eblind, multucentre study was coducted in Europe and South America. In goup of 134 intention-to-treat patients, effective treatment was observed at the end of study in 62%patients treated with terbinafine for 6 weeks and in 63% treated for 8 weeks. Complete cure was observed at the of study in 62 patients treated with terbinafine for 6 weeks, in 60% treated for 8 weeks and in 84% patients treated with griseofulvin for 12 weeks. Terbinafine therarapy for 6 weeks could represent and alternative to griseofulvin for the treatment of Microsporum tineac capitis. However, further clinical trials are required in order to optimize the dose regimen to allow higher cure rates to be reached.

Microsporum species; terbinafine; tinea capitis

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