Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Within-Subject Reliability and between-Subject Variability of Oxidative Stress Markers in Saliva of Healthy Subjects: A Longitudinal Pilot Study (CROSBI ID 251656)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Alajbeg, Iva Z. ; Lapić, Ivana ; Rogić, Dunja ; Vuletić, Lea ; Andabak Rogulj, Ana ; Illeš, Davor ; Knezović Zlatarić, Dubravka ; Badel, Tomislav ; Vrbanović, Ema ; Alajbeg, Ivan Within-Subject Reliability and between-Subject Variability of Oxidative Stress Markers in Saliva of Healthy Subjects: A Longitudinal Pilot Study // Disease markers, 2017 (2017), 2697464, 11. doi: 10.1155/2017/2697464

Podaci o odgovornosti

Alajbeg, Iva Z. ; Lapić, Ivana ; Rogić, Dunja ; Vuletić, Lea ; Andabak Rogulj, Ana ; Illeš, Davor ; Knezović Zlatarić, Dubravka ; Badel, Tomislav ; Vrbanović, Ema ; Alajbeg, Ivan

engleski

Within-Subject Reliability and between-Subject Variability of Oxidative Stress Markers in Saliva of Healthy Subjects: A Longitudinal Pilot Study

The present study evaluated diurnal variations and day-to-day fluctuations of salivary oxidative stress (OS) markers in healthy adult individuals. Whole unstimulated saliva was collected at 2 time intervals over 3 consecutive days. Glutathione peroxidase (GPX), superoxide dismutase (SOD), total antioxidant capacity (TAC), and uric acid (UA) were analyzed using spectrophotometric methods, while 8-hydroxydeoxyguanosine (8-OHdG) and malondialdehyde (MDA) were determined using immunoassays. No significant differences for salivary OS markers between men and women were observed. For all examined OS markers, no significant day-to-day variations were demonstrated. Significant diurnal variations were found in salivary GPX, TAC and MDA levels. For SOD, TAC, GPX, and UA, good-to-moderate intraindividual coefficients of variations (CVs) were observed in more than 75% of the subjects. For MDA and 8-OHdG, intraindividual CVs > 35% were observed in 60% and 40% of the subjects, respectively. Between-subject variance was wide for all examined OS markers (CV% 30.08%-85.70%). Due to high intraindividual variability in the salivary concentrations of MDA and 8-OHdG, those markers cannot be reliably verified based on single measurements and multiple measurements over several days would provide more reliable information. Salivary SOD, TAC, GPX, and UA proved stable across three days of measurement. Trial Registration. ClinicalTrials.gov NCT03029494. Registered on 2017-01-19.

temporomandibular disorders ; oxidative stress markers ; salivary diagnostics ; antioxidants

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

2017

2017.

2697464

11

objavljeno

0278-0240

1875-8630

10.1155/2017/2697464

Povezanost rada

Dentalna medicina, Kliničke medicinske znanosti

Poveznice
Indeksiranost