engleski

Thrombocytopenia in dogs with babesiosis – the role of extracellular histones

There is emerging evidence that platelets are major contributors to inflammatory processes through the cooperation with innate immune cells, in which neutrophils can release DNA fibers with histones to form extracellular traps (NETs). To date, the mechanisms of thrombocytopenia in canine babesiosis include disseminated intravascular coagulation, sequestration in the spleen, increased body temperature and immune-mediated lysis. Circulating histones might also be responsible for thrombocytopenia, as well as for the anemia and leucopenia, and should be taken into account in the approach to the thrombocytopenic patients, where targeting NET formation may be a promising new direction for the treatment of cytopenias in inflammatory diseases.

histones, platelets, babesiosis

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