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izvor podataka: crosbi

Trace elements concentrations association with schizophrenia symptoms; a cross-sectional study in Croatia (CROSBI ID 252742)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Todorić Laidlaw, Ivana ; Mimica, Ninoslav ; Momčilović, Berislav ; Jurasović, Jasna ; Caratan, Sandra ; Filipčić, Igor ; Vuk Pisk, Sandra ; Bajić, Žarko ; Drmić, Stipe Trace elements concentrations association with schizophrenia symptoms; a cross-sectional study in Croatia // Psychiatria Danubina, 30 (2018), 2; 164-171. doi: 10.24869/psyd.2018.164

Podaci o odgovornosti

Todorić Laidlaw, Ivana ; Mimica, Ninoslav ; Momčilović, Berislav ; Jurasović, Jasna ; Caratan, Sandra ; Filipčić, Igor ; Vuk Pisk, Sandra ; Bajić, Žarko ; Drmić, Stipe

engleski

Trace elements concentrations association with schizophrenia symptoms; a cross-sectional study in Croatia

Significant inconsistencies exist in findings on association of bio- elements (BE) concentrations and schizophrenia. Hypothesis of this research was that different concentrations of BE are associated with different psychopathological schizophrenia symptoms.This cross- sectional study was performed from 2014 to 2016 at Psychiatric Hospital "Sveti Ivan" and University Psychiatric Hospital "Vrapče", Zagreb, Croatia, on the consecutive sample of 67 patients diagnosed with schizophrenia. BE concentrations were measured by Inductively Coupled Plasma Mass Spectrometry (ICP- MS) at the Institute for Medical Research and Occupational Health in Zagreb. Severity of schizophrenia symptoms was assessed on Brief Psychiatric Rating Scale (BPRS).After adjustment for all preplanned possible confounding variables, the first canonical correlation between BE and BPRS dimensions variates were statistically significant (Rc2=0.73 ; P=0.006). The first pair of canonical variates is defined by BPRS negative dimension (and marginally by positive symptoms and lack of resistance), and copper (Cu), lead (Pb), lithium (Li) and cobalt (Co) (marginally by cadmium (Cd) and nickel (Ni)).Concentrations of different BE are associated with different schizophrenia symptoms. Maximal correlation between BPRS and BE may be achieved with the weighted linear composite of negative schizophrenia symptoms and copper (Cu), lead (Pb), lithium (Li) and cobalt (Co).

schizophrenia ; bio-elements ; trace elements ; BPRS

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Podaci o izdanju

30 (2)

2018.

164-171

objavljeno

0353-5053

1849-0867

10.24869/psyd.2018.164

Povezanost rada

Kliničke medicinske znanosti

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