engleski

Synthesis of pharmacologically active substituted benzothiazoles

A number of substituted benzothiazoles exhibit useful pharmacological activities [1]. Continuing our studies on the syntheses of some effective compounds against cancer [2] we prepared some new cyano- and amidino-substituted benzothiazoles[3]. Starting with 2-furanacrylic acid or 2-thiopheneacrylic acid in multistep synthesis we obtained corresponding nitriles. Amidines were prepared by the Pinner reaction with isopropylamine. The free base was treated with HCl to generate the wather soluble hidrochloride salts.The antitumor activity of the some prepared compounds “ in vitro” has being investigated. The activity of benzothiazoles were remarcable and dose dependent.

Benzothiazoles ; amidines ; pharmacological activity

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