engleski

Effect of CPAP therapy on neurographic features in male OSA patients with and without sensomotor polyneuropathy

Background and aims: So far, the effect of CPAP therapy on neurographic features of peripheral nerves in OSA patients has not been sufficiently investigated. Objectives: The aim of this study was to determine the effect of CPAP therapy on neurographic features of peripheral nerves in male OSA patients with (n=5) and without ( n=5) peripheral polyneuropathy. Methods: We conducted a cohort study on 10 male OSA patients confirmed by the whole - night polysomnography ( PSG ). All subjects underwent neurological examination and standardised electroneurographic testing of peroneal and sural nerves, before and one year after CPAP therapy. Results: The one-year application of CPAP therapy resulted in the improvement of neurographic features in terms of a significant increase in CMAP and SNAP amplitude values, but also of sensory conduction velocities. Averaged peroneal nerve CMAP amplitudes were 4.64±2.53 mV before and 6.56±1.65 mV after therapy, p=0.001. Averaged SNAP amplitudes were 9.96±5.78 μV at baseline and 15.6±7.28 μV after therapy, p=0.0015. Sensory conduction velocities were 43, 36±3, 90 m/s at baseline and 45.99±5.44 m/s after therapy, p=0.0048. Conclusion: These results confirmed that CPAP therapy is effective in OSA patients with and without peripheral polyneuropathy in terms of an increase in CMAP and SNAP amplitude values and sensory conduction velocities.

CPAP therapy, neurographic features, obstructive sleep apnea, polyneuropathy

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