engleski

Biochemical studies of oximes synthesized in Croatia over the past decades

This paper gives a short review of biochemical research of oximes sythesized in Croatia over the past two decades. The synthesized compounds contained one or two oxime groups at various positions on pyridinium, imidazolium, or quinuclidinium rings. Aromatic rings of some compounds were substituted with aliphatic or aromatic radicals. Biochemical studies of the oximes focused on the mechanism of reversible binding of oximes to cholinesterases, reactivation of phosphorylated cholinesterases, protection of the enzyme against inhibition by the organophosphates (Soman, Sarin, Tabun, VX or DDVP), and interaction of oximes with thiocholine substrates.

acetylcholinesterase; organophosphates; oxime reactivation; oximes synthesis

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