engleski

Clonazepam augmentation during treatment with antipsychotics in aggressive psychiatric inpatients - pilot study

Introduction: The interest in studies related to aggressive behaviour in psychiatric patients has increased over time. Various factors are considered as determinants of aggression, such as social, environmental and situational determinants, hormones, drugs and other substances, neurotransmitters and genetic determinants. Methods: To all patients in a study clonazepam was administered initially in a daily dose of 2 mg. lf satisfactory clinical improvement was not observed in 2 days, it was allowed to increase dose up to a daily dose of 6 mg. Aggression was twice evaluated by Social Dysfunction and Aggression Scale (SDAS): first time at the moment of inclusion to a study, and second time 3 days after the administration of clonazepam. Results: The results of our research show the efficiency of clonazepam as a serenic drug in combination with antipsychotic drug in treatment of aggressive patients. It is particularly encouraging that no adverse effects of clonazepam were observed in this study. Conclusion: Further relevant trials are needed to evaluate use of clonazepam in treatment of long- term/persistent aggression in people living with psychosis.

aggression ; antipsychotic ; clonazepam ; patient ; psychosis

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