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Expression of adhesion molecules on granulocytes and monocytes following myocardial infarction in rats drinking white wine (CROSBI ID 253477)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Režić-Mužinić, Nikolina ; Mastelić, Angela ; Benzon, Benjamin ; Markotić, Anita ; Mudnić, Ivana ; Grković, Ivica ; Grga, Mia ; Milat, Ana Marija ; Ključević, Nikola ; Boban, Mladen Expression of adhesion molecules on granulocytes and monocytes following myocardial infarction in rats drinking white wine // PLoS One, 13 (2018), 5; e0196842, 11. doi: 10.1371/journal.pone.0196842

Podaci o odgovornosti

Režić-Mužinić, Nikolina ; Mastelić, Angela ; Benzon, Benjamin ; Markotić, Anita ; Mudnić, Ivana ; Grković, Ivica ; Grga, Mia ; Milat, Ana Marija ; Ključević, Nikola ; Boban, Mladen

engleski

Expression of adhesion molecules on granulocytes and monocytes following myocardial infarction in rats drinking white wine

Neutrophils and monocytes through their CD15s, CD11b and CD44 adhesion molecules are implicated in the initiation and resolution of cardiac inflammation as well as in healing processes after the myocardial infarction (MI). The aim of this study was to determine the effect of white wine consumption on granulocyte and monocyte CD15s, CD11b, and CD44 expression 24h after the surgically inflicted MI. Granulocytes and monocytes were analyzed by flow cytometry, using whole blood of male Sprague–Dawley rats that consumed white wine for 4 weeks. This group was compared with water only drinking controls, sham animals(subject to surgery without myocardial infarction) and baseline group (intact animals that received no intervention prior to being sacrificed). Sham animals did not differ from baseline animals in CD11b+CD44+ percentage and CD44+ median fluorescence intensity. Wine drinking was associated with striking increase in CD44 expression on monocyte subpopulations. Its expression was three and fourfold increased on monocytes and large monocytes, respectively, relative to the water only drinking controls. Because of known role of CD44 on suppression of post-infarction inflammation, its upregulation on granulocytes and monocytes may significantly contribute to the microenvironment favourable for the cardiac regeneration.

myocardial infarction, white wine, CD11b, CD44, neutrophils, monocytes

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Podaci o izdanju

13 (5)

2018.

e0196842

11

objavljeno

1932-6203

10.1371/journal.pone.0196842

Povezanost rada

Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje), Interdisciplinarne prirodne znanosti, Kemija, Nutricionizam, Temeljne medicinske znanosti

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