engleski

Multimodal ex vivo Mouse Ischemic Brain Lesion Visualization: Quest for a Cross-compatible Fixation Protocol

The assessment of mouse ischemic brain lesion relies greatly on in vivo imaging. However, ex vivo imaging is preferred for observing tissue architecture at higher resolutions, for more accurate mapping of events across the brain. Tissue fixation involves dehydration and structural changes which often reduce MRI signal-to-noise (SNR) and contrast-to-noise (CNR) ratios. Another issue is the incompatibility of tissue preparation protocols for different imaging modalities, such as the use of ethanol in MRI. In this study, we evaluate the cross-compatibility of tissue preparation protocols.

MRI ; synchrotron, mouse ; brain ; ex vivo

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