Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

SAHAquines regulate metalloproteinases in human glioblastioma (CROSBI ID 664765)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Zhang, Issan ; Moquin, Alex ; Beus, Maja ; Zorc, Branka ; Maysinger, Dusica SAHAquines regulate metalloproteinases in human glioblastioma // 23rd Annual Pharmacological Research Day. Montréal: McGill, 2018. str. P34-P34

Podaci o odgovornosti

Zhang, Issan ; Moquin, Alex ; Beus, Maja ; Zorc, Branka ; Maysinger, Dusica

engleski

SAHAquines regulate metalloproteinases in human glioblastioma

Glioblastoma multiforme is the most common and deadly type of brain tumors. Its metastatic potential relies on high levels of matrix metalloproteinases (MMPs) that degrade the extracellular matrix and basement membranes to promote cancer invasion. Although the role of MMPs in cancer is well established, little is known about the effect of chemotherapeutic drugs on their expression and activity. SAHAquines, novel structural analogs of SAHA and primaquine, are lipophilic weak acids found in lysosomes. Lysosomal exocytosis plays a role in cancer drug resistance. Data from our pilot studies suggest that one of the SAHAquines reduces the viability of A1235 glioblastoma, but its effect on lysosomes and MMPs has not been explored.

hybrid molecule ; glioblastoma ; metalloenzymes

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

P34-P34.

2018.

objavljeno

Podaci o matičnoj publikaciji

23rd Annual Pharmacological Research Day

Montréal: McGill

Podaci o skupu

23rd Annual Pharmacological Research Day

poster

14.09.2018-14.09.2018

Montréal, Kanada

Povezanost rada

Kemija, Biologija, Temeljne medicinske znanosti, Farmacija