engleski

High prevalence of CYP2C19*17 allele in the Roma population from Croatia

CYP2C19 gene is a member of cytochrome P450 family that codes for enzymes involved in the biotransformation of many endogenous and exogenous substances. Roma are a transnational minority population with numerous health problems, often treated with drugs metabolised by CYP2C19 enzyme. Ten CYP2C19 loci were genotyped in 440 Roma from Croatia, seven of which were monomorphic (rs28399504, rs4986893, rs55640102, rs56337013, rs72552267, rs72558186 and rs41291556). Minor allele frequency (MAF) of rs4244285 in the Roma population was 15.5%, similar to the surrounding Croatian population, and MAF of rs12248560 (CYP2C19*17) was 28.3%, higher not only compared to Croatian population, but also to other world populations. MAF of rs3758581 in the Croatian Roma was 18.3%, which is also notably higher than in other populations. Genetic profile of CYP2C19 in Croatian Roma might be the result of reproductive isolation and definitelly should be taken into account in prescribing drugs, to prevent adverse drug reactions.

ADME ; CYP2C19 ; pharmacogenetics ; Roma ; Croatia

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