Tumor-associated macrophages in invasive breast cancer (CROSBI ID 465502)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Jonjić, Nives ; Lučin, Ksenija ; Mustać, Elvira ; Sasso, Franco ; Valković, Toni ; Melato, Mauro
engleski
Tumor-associated macrophages in invasive breast cancer
Tumor-associated macrophages (TAM) have several functions related to tumor biology including growth and proliferative rate, stroma formation and dissolution, neovascularisation. Monocyte chemotactic protein-1 (MCP-1) is a chemokine which induces chemotactic migration of leukocytes, particularly monocytes. The aim of our study was to define the TAM density in 81 invasive breast carcinomas and to correlate TAM density values with lymph node status, tumor grade and size, mitotic activity index (MAI) and microvesel count. MCP-1 expression was considered in order to explore its role in regulating macrophages infiltration. Widespread macrophage infiltrates were significantly more frequent in tumors ranging from 1 to 2 cm if compared to those smaller than 1 cm of bigger than 2 cm (p=0,023). Furthermore, statistical analysis showed a positive association between macrophages density and MAI (p=0,042). No correlation between macrophages density and lymph node involvement, tumor grade, microvessels count was found. Furthermore, TAM levels and MCP-1 expression were not correlated. According to our results on invasive breast cancer, MCP-1, a tumor derived chemotactic factor, is not involved in regulation of monocyte extravasation although these cells, being correlated to MAI, play a role in tumor growth.
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
4040-4040-x.
1997.
objavljeno
Podaci o matičnoj publikaciji
Abstracts of the IIAR Conferences 1997, Anticancer Research 17 (1997), 6A
Delinassios, J. G ; Azoudis, S ; Iliadis, E.
Atena: International Institute of Anticancer Research
Podaci o skupu
International Conference on Gene Therapy in Cancer
predavanje
27.09.1997-30.09.1997
Atena, Grčka