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izvor podataka: crosbi

Chloroquine urea derivatives: synthesis and antitumor activity in vitro (CROSBI ID 254798)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Pavić, Kristina ; Rajić, Zrinka ; Mlinarić, Zvonimir ; Uzelac, Lidija ; Kralj, Marijeta ; Zorc, Branka Chloroquine urea derivatives: synthesis and antitumor activity in vitro // Acta pharmaceutica, 68 (2018), 4; 471-483. doi: 10.2478/acph-2018-0039

Podaci o odgovornosti

Pavić, Kristina ; Rajić, Zrinka ; Mlinarić, Zvonimir ; Uzelac, Lidija ; Kralj, Marijeta ; Zorc, Branka

engleski

Chloroquine urea derivatives: synthesis and antitumor activity in vitro

In the current paper, we describe the design, synthesis and antiproliferative screening of novel chloroquine derivatives with a quinoline core linked to a hydroxy or halogen amine through a flexible aminobutyl chain and urea spacer. Synthetic pathway leading to chloroquine urea derivatives 4–10 includes two crucial steps: i) synthesis of chloroquine benzotriazolide 3 and ii) formation of urea derivatives through the reaction of compound 3 with the corresponding amine. Testing of antiproliferative activity against four human cancer cell lines revealed that chloroquine urea derivatives 9 and 10 with aromatic moieties show activity at micromolar concentrations. Therefore, these molecules represent interesting lead compounds that might provide an insight into the design of new anticancer agents.

Chloroquine ; Hydroxychloroquine ; Urea ; Antitumor activity in vitro

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Podaci o izdanju

68 (4)

2018.

471-483

objavljeno

1330-0075

1846-9558

10.2478/acph-2018-0039

Trošak objave rada u otvorenom pristupu

Povezanost rada

Kemija, Temeljne medicinske znanosti, Farmacija

Poveznice
Indeksiranost