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Biocompatible nanoparticles with flavonoids in food products mission

Flavonoids have a key role in plant growth and development and their protection from all kinds of environmental stress like UV radiation, heat, coldness and numerous parasites [1]. In spite of their extraordinary therapeutic potential, their use is very limited because of low solubility in water and fast metabolic degradation in organism. Bioavailability of quercetin when applied orally is only 1% in humans. When applied intravenously, from the initial concentration of 100 mg in plasma, after 3 hours only micromolar concentrations are present. Flavonoid loading of nanoparticles (NP) could significantly improve the oral administration of flavonoids, protecting them from degradation in digestive tract and ensure extended release of the active substance. In order to fulfil these requirements, NP must also be stable enough. Two investigated groups of NP are inorganic and organic NP. However, neither one of them possesses the wanted properties. The goal of our work was making of a functional prototype of biodegradable NPs having built-in flavonoids as an original solution up to date not present on the market. Such NP have a capacity of flavonoid integration greater then presently achieved 2 % of NP mass [2] and ability of controllable release. NP will resolve the problem of chemical instability of flavonoids and their low solubility in water. Specifically, the activity of myricetin and myricitrin, was investigated. Myricetin exhibits strong activity in radical scavenging. Myricitrin exhibits an extraordinary antioxidative, anti-inflammatory and anti-nociceptive activity [3]. As a reference quercetin was used. There are two possible types of projects risks: a) NPs will not possess the expected capacity of flavonoid adsorption and b) NPs loaded with flavonoids will not release them in satisfactory rate. The developed NPs prototype with a high capacity for flavonoid incorporation primarily intended for the food industry and biotechnology contributes to the recognition of flavonoid organization within nanostructured nanotubes and provides a deeper insight into the flavonoid release mechanism at the molecular level, depending on the medium in which NP is applied. A huge potential for the use of mesoporous silica NPs has been confirmed to incorporate not only flavonoids as bioactive molecules, but also other drugs. The direction of their further development depends on their application in several areas: a) In the food industry and biotechnology, it is necessary to further optimize for their specific application, e.g. NPs as stabilizers in the preservation of food oils and their products. For this purpose, functionalized NPs with the overlays would have been developed that would have the appropriate stability and controlled release of bioactive molecules whether in water or in the non-aqueous medium. Furthermore, the process would also be formulated adaptation of multifunctional NPs production from laboratory conditions to industrial level. b) new directions for specific functionalization of NPs and optimization and selection of NP coatings would be developed to obtain NPs that could potentially be found in the pharmaceutical industry and nano-medicine as - of various drugs under physiological conditions.

Biodegradible silica nanoparticles ; flavonoids ; temperature controlled release

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