Effects of aluminum chloride on lipid peroxidation and distribution of toxic and essential/trace elements in rats liver and spleen tissues (CROSBI ID 666191)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Kukolj, Marina ; Oršolić, Nada ; Odeh, Dyana ; Orct, Tatjana ; Šimić, Goran ; Horvat Langer, Lea ; Šoštarić, Branko ; Branović Čakanić, Karmen ; Grabarević, Dunja ; Terzić, Svjetlana
engleski
Effects of aluminum chloride on lipid peroxidation and distribution of toxic and essential/trace elements in rats liver and spleen tissues
Aluminum (Al) is a nonessential, toxic element which is assoiated with number of disorders in people (e.g. Alzheimer's disease). While, hematopoietic organs (liver and spleen) are the vital sites involved in detoxification. This study was aimed to explore antioxidative and detoxifying capacity of the liver and spleen after administration of aluminum chloride. Twelve male Y59 rats were intraperitoneally administered with: (a) 0, 9% NaCl (control group) and (b) AlCl3 (10 mg/kg) and D-(+)- galactose (60 mg/kg) per day consecutively for 28 days. The analysis of essential and toxic elements in the liver and spleen tissues was performed by mass spectrometry inductively coupled plasma (ICP-MS). Lipid peroxidation (LP) was measured by thiobarbituric acid assay in homogenates of liver and spleen. The results showed statistically significant increase of toxic metals (Al, Cd, As) in liver and spleen tissues, also essential/trace elements in liver (Co, Sr, Mo P, S, Ca, Fe, Cu, Zn, Se, Na, Mg) and spleen (Mo, Ca, Fe, Se) tissues of rats treated with AlCl3 compared to the control group. While P, S, Mn, Zn, Mg in the spleen was significantly reduced. The level of LP was significantly increased in spleen tissues of AlCl3-treated rats. The results indicate that AlCl3 interfere with the metabolic function of the liver and leads to disruption of trace element, while spleen has less changes in the essential elements but higher sensibility to proxidative effect of AlCl3.
aluminum chloride ; toxic elements ; essential elements ; detoxification
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
330-331.
2018.
objavljeno
Podaci o matičnoj publikaciji
13th Croatian Biological Congress with International Participation: book of abstracts
Kružić, Petar ; Caput Mihalić, Katarina ; Gottstein, Sanja ; Pavoković, Dubravko ; Kučinić, Mladen
Podaci o skupu
13th Croatian Biological Congress with International Participation
poster
19.09.2018-29.09.2018
Poreč, Hrvatska
Povezanost rada
Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje), Kemijsko inženjerstvo