engleski

Antioxidative Activity of Caffeic Acid: Applicability in Diabetes

Diabetes mellitus is a disease with high growth rate. The present study was designed to investigate the possible antidiabetic and protective effect of caffeic acid against alloxaninduced oxidative damage in diabetic mice. Type 1 diabetes was induced in mice by injection alloxan in dose of 75 mg kg-1 bwt iv. After 9 days of alloxan injection, there was an apparent reduction in the animal body weight and significant increase in serum glucose, triglyceride and total cholesterol levels as compared to the control healty mice. Treatment of diabetic mice with caffeic acid in dose of 50 mg kg-1 for seven days reduced the decline in body mass, % hemolysis of erythrocytes, blood triglyceride and cholesterol levels and increased functional activity of macrophages peritoneal cavity but did not increase the survival of mice. Additionally comet assay results show that treatment of diabetic animals with caffeic acid reduces the alloxan-induced DNA damage to lymphocytes. The results indicate that caffeic acid has promising effects in reducing negative consequences of developing diabetes, which contributes to its antioxidant potential.

diabetes, oxidative stress, aloxan, caffeic acid, comet assay

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