engleski

The expression of insulin-like growth factor 2 (IGF2) in patients with oral lichen planus and diabetes mellitus

Introduction: Insulin-like growth factor 2 (IGF2) has growth promoting and proliferating effect on different cell types. Increased risk of cancer development was observed in patients with type 2 diabetes mellitus, while oral lichen planus is known as premalignant lesion. Objectives: The aim of this study was to examine the expression of IGF2 in patients with oral lichen planus(OLP) and type 2 diabetes mellitus (DM). Material and methods: IGF2 expression was evaluated in paraffin-imbedded biopsy samples of oral mucosa of total of 8 patients with oral lichen planus and diabetes mellitus (OLP+DM) and 8 patients with oral lichen planus without diabetes mellitus (OLP), by comparative semiquantitative immunohistochemistry. IGF2 expression was interpreted according to the literature. A score of 0–5 was considered negative (low expression of IGF2), and a score of 6 was considered positive (high expression of IGF2). Results and conclusions: All biopsy samples in both groups of patients had negative score of IGF2 expression. Biopsy samples of OLP+DM patients had lower scores of IGF2 expression when compared to OLP group, and the difference was statistically significant (Mann-Whitney test for independent samples ; P = 0, 0014). Immunohistochemical analysis of IGF2 expression has determined variable immunoreactivity with a significant difference in final scores of IGF2 staining in biopsy samples of patients with oral lichen planus with and without diabetes mellitus, although all results were considered negative. This was a pilot study with small number of patients and further investigation on larger group of samples is required.

IGF2 ; OLP ; diabetes

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