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The members of Wnt pathway SFRP1, SFRP3, and DVL1 are down regulated in testicular germ cell tumours (CROSBI ID 667670)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Fabijanović, Dora ; Žunić, Iris ; Nikuševa Martić, Tamara ; Škenderi, Faruk ; Šerman, Ljiljana ; Vranić, Semir The members of Wnt pathway SFRP1, SFRP3, and DVL1 are down regulated in testicular germ cell tumours // Virchows Archiv. Springer, 2016. str. 218-219

Podaci o odgovornosti

Fabijanović, Dora ; Žunić, Iris ; Nikuševa Martić, Tamara ; Škenderi, Faruk ; Šerman, Ljiljana ; Vranić, Semir

engleski

The members of Wnt pathway SFRP1, SFRP3, and DVL1 are down regulated in testicular germ cell tumours

Objective: Wnt signaling pathway components have been shown to be actively involved in normal and malignant germ cell differentiation and progression. In the present study, we aimed to explore the expression patterns of two of the Wnt pathway members, the secreted frizzled- related protein (SFRP) and Dishevelled protein family (DVL) in a subset of testicular germ cell tumours. Method: Eighty-five formalin- fixed paraffin-embedded tissue samples of the primary germ cell tumours of the testis were stained against SFRP1, SFRP3, DVL1, and DVL2 proteins using immunohistochemistry. Results: SFRP1 and SFRP3 exhibited lower expression in both seminomas and mixed/non-seminomatous tumours, compared with normal tissue (p < 0.001). SFRP3 expression was lower than SFRP1 expression within the seminoma group (p = 0.004), but not within the mixed/non- seminomatous group (p = 0.409). The majority of the tested cases (27/28, 96 %) exhibited low DVL1 protein expression (mean 9.6 %). In contrast, 20 out of 22 tested cases (91 %) exhibited a strong overexpression of DVL2 protein (mean 68.6 %, range 0–100 %). Conclusion: The secreted frizzled-related protein and dishevelled protein family members show different expression profiles in tumours, compared to normal tissue, suggesting their role in the pathogenesis of testicular germ cell tumours. Further molecular and clinical studies should confirm the relevance of our findings.

Wnt signaling pathway, SFRP1, SFRP3, DVL1, DVL2, testicular tumours

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Podaci o prilogu

218-219.

2016.

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objavljeno

Podaci o matičnoj publikaciji

Virchows Archiv

Springer

Podaci o skupu

XXXI International Congress of the International Academy of Pathology and 28th Congress of the European Society of Pathology

poster

25.09.2016-29.09.2016

Köln, Njemačka

Povezanost rada

nije evidentirano

Poveznice