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Similarities in the Pattern of Regional Brain Dysfunction in Negative Schizophrenia and Unipolar Depression: A Single Photon Emission-Computed Tomography and Auditory Evoked Potencials Study

Abstract: 1. Negative schizophrenic and unipolar depressive patients were clinically assessed. In addition to thisSANS and HRSD tests were administered. 2. SPECT and AEP measurements were provided. SPECT resulted in quantified brain blood perfusion, by means of average "count/pixel" values in the brain regions of interest. AEPs resulted in stored multichannel signal waveforms. 3. Statistical analyses of blood perfusion measurement data revealed an overall similarity between these two disorders in the majority of brain regions. An exception to this are the regions: inferior temporal is, inferior occipitalis, hippocampus and the anterior basal ganglia. Both diagnostic groups manifested hypofrontality. In general, hypoperfusion of the left hemisphere was found, albeit displaying different patterns in the two groups investigated. 4. AEP latencies were prolonged and found to be similar in both diagnostic groups, whilst AEP amplitudes were smaller in schizophrenics compared to depressives.

auditory evoked potentials (AEPs); biological psychiatry; depression; frontal brain regions; schizophrenia; single photon emission-computed tomography (SPECT)

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