engleski

Pharmacological and toxicological health risk of food (herbal) supplements adulterated with erectile dysfunction medications

Erectile dysfunction is one of the most common sexual disorders among men, with large number of patients worldwide. This is a multifactorial disease with (non)organic causes while main oral drugs for the treatment are phosphodiesterase type 5 inhibitors (PDE5Is). Currently, sildenafil, vardenafil, tadalafil, udenafil, mirodenafil, lodenafil and avanafil are used. Worldwide use of herbal and dietary supplements for alleviating this problem is on a rise, as many consumers perceive these products as ‘healthier’ and safer as compared to conventional pharmaceutical preparations. However, adulteration of food supplements with PDE5Is and/or its analogues is very common and represents serious public health concern. This review address the issues with pharmacological and toxicological health risks of food supplements adulterated with erectile dysfunction medications.

food supplements for erectile dysfunction ; phosphodiesterase type 5 inhibitors (PDE5Is) ; adulterated sildenafil ; tadalafil ; vardenafil ; avanafil

Inozemne institucije koautora na radu: Department of Food Engineering, State University of Ponta Grossa, Ponta Grossa, Brazil