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Histological properties of sagittal axonal strata in developing fetal human brain (CROSBI ID 669990)

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Žunić Iris ; Kostović Ivica Histological properties of sagittal axonal strata in developing fetal human brain. 2017. str. 59-59

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Žunić Iris ; Kostović Ivica

engleski

Histological properties of sagittal axonal strata in developing fetal human brain

The growth and establishment of projection trajectories and termination of long-range cortical axonal pathways mainly occur during prenatal-neonatal period, representing crucial neurogenetic events in the human brain. This period consists of sequential growth of thalamocortical, commissural and associative pathways within transient laminar compartments of developing cerebral wall. In late fetus, geometry and topography of white matter is defined through five segments, according to Von MOnakow, giving us opportunity for better understanding of the selective vulnerability of different classes of axonal pathways within cerebral compartments. Sagittal strata (SS), placed in the secon segment of white matter, are cortico-subcortical and cortico-cortical fiber pathways, showing complex stratified arrangement. Our aim is to analyze spatio- temporal characteristics of sagittaly running fibers in SS and their relationship with different cellular and histogenetic events of the developing cerebral wall of the fetal human brain. 20 postmortem brains from Zagreb Neuroembryological Collection, age ranging from 9 to 36 PCW, were stained for different cellular, fibrillar and proliferative markers. The earliest appearance of SS occurs between 10.5-12 PCW, when it is possible fot the first time to visualize division of sagittaly running fibers into one deep internal stratum (ISS) and one superficial external sagittal stratum (ESS) corresponding to external capsule. The ISS may be followed to internal capsule and thalamaus and ESS may be followed to basal forebrain. During subplate formation stage (13-15 PCW), fibers of both ESS and ISS, enter to deep portion of cortical plate (CP) and contribute to the formation of subplate. During midgestation (16-22PCW), thalamic fibers situated in ISS and basal forebrain fibers situated in ESS, grow in tangential direction towards frontal and occipital pole. SS participate in local architecture of dispersion of proliferative cells in subventricular zone and migratory waves of cells, which leads to complex multilaminar structure. First signs of developing associative fiber system appear as narrow AChE negative stained band external to ESS. From 22-36, sagittakky runing fibers, originating from thalamus and basal forebrain, accumulate beyond CP and gradually penetrate CP. Distribution of proliferative and glial markers, together with migratory neurons, confirms that SS alternate with cell rich bands of the outer subventricular zone. Approaching to newborn period, all types of fiber system are already present in SS and pericalcarine cortex shows precautious myelination. Sagittally running fiber system of lon range patwhays shows continuity from early fetal to newborn period. During fetal growth, meadially runinning sagittal fibers grow through outer subventricular zone and separate this one into several proliferative laminas. Fibers of ESS compose fetal intermediate zone and contain both projection fibers, from bazal forebrain and thalamus, and associative fibers of inferior fronto-occipital fascicle. It is our proposal that precise stratified arrangement of sagittal fibers and associated proliferative cell layers may serve as reliable indicator of white matter integrity, and also as normative data for studying perinatal hypoxic- ischemic lesions of preterm infants.

sagittal strata ; fetal human brain ; white matter integrity

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Podaci o prilogu

59-59.

2017.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Podaci o skupu

6. CROATIAN NEUROSCIENCE CONGRESS,

poster

16.09.2017-18.09.2017

Osijek, Hrvatska

Povezanost rada

Temeljne medicinske znanosti