Electrostatics-Driven Inflation of Elastic Icosahedral Shells as a Model for Swelling of Viruses (CROSBI ID 257954)
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Lošdorfer Božič, Anže ; Šiber, Antonio
engleski
Electrostatics-Driven Inflation of Elastic Icosahedral Shells as a Model for Swelling of Viruses
We develop a clear theoretical description of radial swelling in virus-like particles that delineates the importance of electrostatic contributions to swelling in the absence of any conformational changes. The model couples the elastic parameters of the capsid—represented as a continuous elastic shell—to the electrostatic pressure acting on it. We show that different modifications of the electrostatic interactions brought about by, for instance, changes in pH or solution ionic strength are often sufficient to achieve the experimentally observed swelling (∼10% of the capsid radius). Additionally, we derive analytical expressions for the electrostatics-driven radial swelling of virus like particles that enable one to quickly estimate the magnitudes of physical quantities involved.
virus ; elasticity ; swelling ; electrostatics
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