engleski

Inflammatory response following peripheral endovascular treatment correlates with the extent of periprocedural arterial injury

Purpose: To examine whether the postprocedural change in CRP and fibrinogen levels is associated with the extent of periprocedural arterial injury caused by endovascular treatment (EVT). Patients and methods: This study recruited seventy-one patients who underwent EVT. Eighty-four patients who underwent angiography served as a control group. C-reactive protein (CRP) and fibrinogen were measured at baseline, and 8, 24 and 48 hours following the procedure. For all patients in the study group, lesion complexity, PTA treated segment length, balloon inflation time and stented segment length were recorded. Results: There was significant increase in plasma CRP and fibrinogen levels 48 hours following EVT (P<0.001). No significant difference in CRP and fibrinogen levels was found between different TASC groups. CRP levels were significantly higher in stent subgroup compared to PTA subgroup. Significant positive correlation was found between PTA treated segment length and CRP increase between 8 and 24 hours following EVT (r=0.313, P=0.02), balloon inflation time and CRP increase in the aforementioned time frame (r=0.270, P=0.03), as well as between CRP increase in after 8 hours and the stented segment length (r=0.535, P=0.01). Conclusion: This study has shown that the arterial injury caused by EVT reflects on the level of inflammatory biomarkers.

C-reactive protein ; Endovascular Therapy ; Fibrinogen ; Inflammatory Cytokines ; Percutaneous Transluminal Angioplasty ; Stents

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