Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Oxidative stress as a mechanism of combined OTA and CTN toxicity in rat plasma, liver and kidney (CROSBI ID 258282)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Rašić, Dubravka ; Micek, Vedran ; Šegvić Klarić, Maja ; Peraica, Maja Oxidative stress as a mechanism of combined OTA and CTN toxicity in rat plasma, liver and kidney // Human & experimental toxicology, 38 (2019), 4; 434-445. doi: 10.1177/0960327118819049

Podaci o odgovornosti

Rašić, Dubravka ; Micek, Vedran ; Šegvić Klarić, Maja ; Peraica, Maja

engleski

Oxidative stress as a mechanism of combined OTA and CTN toxicity in rat plasma, liver and kidney

Ochratoxin A (OTA) and citrinin (CTN) commonly coexist in grains. Aiming to evaluate oxidative stress in OTA + CTN toxicity, male Wistar rats were orally treated with two doses of OTA (0.125 and 0.250 mg kg−1 of body weight (b.w.)), CTN (2 mg kg−1 of b.w.) and resveratrol (RSV ; 20 mg kg−1 of b.w.) and combined daily during 3 weeks. Protein carbonyl concentrations were measured in kidneys and liver ; catalytic activity of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) level in plasma, kidneys and liver, while malondialdehyde (MDA) concentration was measured in plasma, kidneys, liver and urine. Mycotoxin treatment significantly increased MDA concentration in plasma and kidney and decreased SOD activity in the liver. Rats treated with CTN and OTA125 + CTN had lower plasma GPx activity. Concentration of GSH in the kidney and protein carbonyls in the kidney and liver as well as GPx activity in the kidney and liver, SOD activity in the kidney and CAT activity in the liver were not affected. Protective effect of RSV was observed on GSH in the kidney and plasma and MDA in the kidney, plasma and urine. Oxidative stress is involved in OTA + CTN toxicity in vivo because such treatment affects parameters of oxidative stress, particularly in plasma. RSV can reduce but not overcome oxidative stress induced by combined OTA and CTN treatment.

Citrinin, ochratoxin A, oxidative stress, rats, resveratrol

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

38 (4)

2019.

434-445

objavljeno

0960-3271

1477-0903

10.1177/0960327118819049

Povezanost rada

Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Farmacija

Poveznice
Indeksiranost