Effects of melatonin and resveratrol on telomere dynamics in liver and kidneys in 1- and 2-year-old Wistar rats (CROSBI ID 671746)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Nanić, Lucia ; Gerić, Marko ; Gajski, Goran ; Jurasović, Jasna ; Karaica, Dean ; Ljubojević, Marija ; Micek, Vedran ; Novak Jovanović, Ivana ; Orct, Tatjana ; Peraica, Maja ; Rašić, Dubravka ; Vrhovac Madunić, Ivana ; Sabolić, Ivan ; Breljak, Davorka ; Rubelj, Ivica
engleski
Effects of melatonin and resveratrol on telomere dynamics in liver and kidneys in 1- and 2-year-old Wistar rats
Telomeres are the main guardians of genome stability. During DNA replication, progressive shortening of telomeres takes place with each cell division. Critically short telomeres induce cell cycle arrest or apoptosis. Oxidative stress also plays an important role in telomere dynamics. Recent evidence highlights direct molecular connection between telomere attrition and mitochondrial dysfunction. Although reactive oxygen species (ROS) are normal products in intermediary metabolism, and are crucial for different intracellular signalling pathways, a disbalance resulting in ROS excess induces oxidative stress and accelerates telomere shortening. It is assumed that with ageing, production of ROS may be increased causing faster telomere shortening, and that both may be ameliorated by antioxidants. To test this hypothesis, we treated male and female Wistar rats for 9 or 21 months with melatonin and resveratrol and investigated their effect on telomere attrition rate in liver and kidney (various zones) tissues. Telomere length was assessed by Southern blotting of genomic DNA. The results in 1- and 2- year-old male and female rats showed an absence of significant differences in telomere length in the tissues from both organs after treatment with antioxidants compared to control (vehicle-treated) animals (N=4 per group). Based on obtained results, we did not observe beneficial properties of tested antioxidants towards age-dependent telomere shortening.
telomeres ; reactive oxigen species ; melatonin ; resveratrol ; rats
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Podaci o prilogu
56-56.
2018.
objavljeno
Podaci o matičnoj publikaciji
4th Congress of Croatian Geneticists with International Participation : Book of abstracts
Šarčević, Hrvoje ; Ugarković, Đurđica ; Vujaklija, Dušica ; Krešimir, Ivan S. ; Svetec Miklenić, Marina
Zagreb: Hrvatsko genetičko društvo
978-953-57128-1-7
Podaci o skupu
4th Congress of Croatian Geneticists with international participation
poster
26.09.2018-29.09.2018
Krk, Hrvatska