engleski

Alpha satellite RNA and MSH2 gene: potential candidates for diagnostic/prognostic blood's biomarker of prostate cancer

Prostate cancer is the second most common cancer among men in Croatia. The clinically most accepted biomarker for prostate cancer diagnosis is PSA (prostate-specific antigen), but due to the lack of its specificity intensive efforts are currently directed towards a search for alternative diagnostic and prognostic prostate cancer biomarkers. Biomarker is defined as a biological molecule found in blood, other body fluids, or tissues that can be objectively measured and evaluated as a sign of a normal or abnormal biological process and a pathogenic condition/disease. The aim of this research was to check alteration of expression of two proposed biomarker candidates in the blood of prostate cancer samples compared with healthy controls. As observed downregulation was statistically significant, alpha satellite RNA and MSH2 gene are proposed as candidates for non-invasive diagnostic/prognostic biomarkers of prostate cancer.

blood ; molecular markers ; downregulation ; non-invasive method

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