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Polyphenolic flavonoids and metalloprotease inhibition: Applications to health and disease

Flavonoids belong to the group of naturally occurring polyphenolic compounds ubiquitously found in plants. They are important components of human diet and have various biological activities. The ability of flavonoids to coordinate metal ions and to interact with peptidases whose catalytic activity depends on the metal cation is an important cause for their beneficial effects on human health. To date, numerous flavonoid compounds as inhibitors with pathophysiological significance in the regulation of human metalloprotease activity are known and are widely used for scientific and pharmaceutical studies. This review presents an overview of the investigations on the feasibility and application of flavonoids as natural inhibitors for well-known human metalloproteases: matrix metalloproteinases and angiotensin-converting enzyme.

polyphenolic compound ; flavonoid ; inhibitor ; metalloprotease ; matrix metalloproteinase ; angiotensin-converting enzyme ; human health disease

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