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Phenolic compounds of Iris adriatica and their antimycobacterial effects (CROSBI ID 261593)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Ochensberger, Sandra: Alperth, Fabian ; Mitić, Božena ; Kunert, Olaf ; Mayer, Stefanie ; Ferreira Mourão, Maria ; Turek, Ivana ; Vlad Luca, Simon ; Skalicka-Woźniak, Krystyna ; Maleš, Željan ; Hruševar, Dario et al. Phenolic compounds of Iris adriatica and their antimycobacterial effects // Acta pharmaceutica, 69 (2019), 4; 673-681. doi: 10.2478/acph-2019-0037

Podaci o odgovornosti

Ochensberger, Sandra: Alperth, Fabian ; Mitić, Božena ; Kunert, Olaf ; Mayer, Stefanie ; Ferreira Mourão, Maria ; Turek, Ivana ; Vlad Luca, Simon ; Skalicka-Woźniak, Krystyna ; Maleš, Željan ; Hruševar, Dario ; Duka, Ivan ; Bucar, Franz

engleski

Phenolic compounds of Iris adriatica and their antimycobacterial effects

Little is known about the pharmacological activities of Iris adriatica (Iridaceae), a plant en-demic to Dalmatia (Croatia). For this purpose, we performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and antibacterial tests using Mycobacterium smegmatis mc² 155. One obtained fraction was found to be antimyco- bacterially active with a MIC of 64 mg L-1. Furthermore, fractions were tested for resistance modulatory effects using ethidium bromide as substrate. We were able to identify the pure isoflavonic compounds irigenin and irilone and a fraction containing mainly the benzophenone 2, 4, 6-trihydroxy-4- methoxy-benzophenone to be responsible for the resistance-modulatory activity of this plant.

Iris adriatica, Radix Iridis, phenolic compounds, Mycobacterium smegmatis, resistance modu-lation, ethidium bromide, MIC

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Podaci o izdanju

69 (4)

2019.

673-681

objavljeno

1330-0075

1846-9558

10.2478/acph-2019-0037

Povezanost rada

Biologija, Farmacija

Poveznice
Indeksiranost