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Interference sample as a source of preanalytical variablity: results of Croatian preanalytical External Quality Assessment CROQALM program (CROSBI ID 673970)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Nikolac Gabaj, Nora ; Ćelap, Ivana ; Leniček Krleža, Jasna Interference sample as a source of preanalytical variablity: results of Croatian preanalytical External Quality Assessment CROQALM program // Clinical chemistry and laboratory medicine / Plebani, Mario (ur.). 2019. str. eA72-eA73 doi: 10.1515/cclm-2019-0104

Podaci o odgovornosti

Nikolac Gabaj, Nora ; Ćelap, Ivana ; Leniček Krleža, Jasna

engleski

Interference sample as a source of preanalytical variablity: results of Croatian preanalytical External Quality Assessment CROQALM program

BACKGROUND-AIM: The aim of this study is to present results of distributing icteric sample within Croatian preanalytical External Quality Assessment (EQA) provider CROQALM. METHODS: All Croatian laboratories (N = 194) were invited to participate in free-of-charge preanalytical EQA during 2018. In March (Sample 1) and September (Sample 3) serum sample for clinical chemistry, while in June (Sample 2) citrate plasma for coagulation were distributed. Samples were prepared as follows: leftover serum/citrate plasma samples without any visible interference were collected, mixed, immediately frozen at -20 °C for 48 hours, thawed and filtered once using filter paper. Pools were spiked with powdered bilirubin (Sigma-Aldrich, Missouri, USA) in order to create icteric samples. Samples were aliquoted and sent out to laboratories within 48 hours. Participants were asked to evaluate the degree of interference. Responses were collected via service SurveyMonkey (California, USA). Variables were compared using Chi-square test in MedCalc (v12.7.2.0, Ostend, Belgium). P < 0.05 was considered statistically significant. RESULTS: Majority of laboratories evaluate icteria visually (108/161, 67.1% ; 140/148, 94.6% ; 101/156, 64.7% in cycles 1-3, respectively) with lower representation of automatic evaluation in coagulation (cycle 2 ; P < 0.001). When asked to visually evaluate the sample, 109/157, 69.4% ; 103/144, 71.5% ; 101/153, 66% gave the preferred answer (“icteric sample”), no differences between cycles were observed (P = 0.450). Out of laboratories using automatic evaluation of icteria, significantly more expressed index quantitatively in cycle 3 vs. 1. (78.8% vs. 42.2% ; P < 0.001). No laboratory provided data on automatic index in coagulation cycle. 2/3 of laboratories express I index in μmol/L. CONCLUSIONS: Large variability between Croatian laboratories was observed in management of icteric sample, with automatic evaluation being more implemented in clinical chemistry than in coagulation.

preanalytical phase, external quality assessment, interference, icteria

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Podaci o prilogu

eA72-eA73.

2019.

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objavljeno

10.1515/cclm-2019-0104

Podaci o matičnoj publikaciji

Clinical chemistry and laboratory medicine

Plebani, Mario

Berlin: Walter de Gruyter

1434-6621

Podaci o skupu

5th EFLM Conference on Preanalytical Phase

poster

22.03.2019-23.03.2019

Zagreb, Hrvatska

Povezanost rada

Kliničke medicinske znanosti

Poveznice
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