engleski

Absolute configuration of 2, 6-dimethylheptyl sulfate and its distribution in Ascidiacea

2, 6-Dimethylheptyl sulfate (1) was isolated for the first time from a marine ascidian from Polycitor adriaticus Drasche (class Ascidiacea, order Aplousobramchiata, family Polycitoridae). In this work, the absolute stereochemistry at C-2 of 1 was determined by 1H-NRM analysis of its (+)- and (-)-methoxy(trifluoromethyl)phenylacetic acid (MTPA) esters (Mosher's method). The distribution of 1 was investigated among the three orders (Aplousobranchiata, Phlebobranchiata, and Stolidobranchiata) of the slass Ascidiacea. Compound 1 showed cytotoxicity (LC50=17.8 ľg/mL) in the Artemia salina bioassay and was not toxic (not toxicity at 100 ľg/mL) in a fish (Gambusia affinis) lethality assay.

polycitor adriaticus; 2.6-dimethylheptil; ascidiacea

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