engleski

HLA-Cw ALLELES IN PATIENTS WITH PSORIATIC ARTHRITIS

Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. Case control studies of HLA-Cw polymorphism have found that Cw*0602 allele is associated with PsA. The aim of this investigation was to compare the frequency of alleles at the HLA-Cw locus in patients with PsA to that in the control population. Fifty consecutive patients attending the Clinic of Rheumatology between January and November 2001 and 144 unrelated healthy individuals were studied. HLA typing was performed by both serologic and PCR-SSP method, while Chi-squared test with Yate's correction and the Fischer's exact test were used to compare the frequency of HLA alleles in the patients and controls. HLA-Cw*07 allele was present in 20 patients and 16 controls: allele frequency of 21% in the patients versus 5.7% (p<0.001) in controls. HLA-Cw*0602 allele was present in 12% of the PsA patients, compared with 4.9% of controls (p<0.01). The relative risk (RR) for these two alleles was 5.3 and 3.3, respectively. No statistically significant difference for all other Cw alleles between two groups was observed. In conclusion, study with larger number of PsA patients is necessary to confirm this finding and to elucidate the significance of HLA-Cw*07 allele in the susceptibility to PsA in our population.

HLA-Cw; PsA

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