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Strontium/carbonate co-substituted two-phase system of hydroxyapatite and octacalcium phosphate derived from cuttlefish bone

Hydroxyapatite (HAp) is the most widely used calcium phosphate (CaP) for hard tissue applications due to its compositional simi-larity to biological apatite, biocompatibility and bioactivity. Along with HAp, other CaPs, such as octacalcium phosphate (OCP) and tricalcium phosphates (TCP), are gaining increasing attention. As bone apatite is a multi-substituted carbonated HAp containing trace elements, one of the used approach to improve the biolog-ical and physicochemical properties of CaPs is ionic substitution. In this study Sr-substituted CaPs, with varying Sr-dopant content, have been prepared by using cuttlefish bone as precursor of Ca2+ and various trace ions. The effect of the doping on phase composition, crystal structure, morphology and thermal stability of synthesized materials was studied. Mineralogical composition of the as-pre-pared powders and the heat-treated powders were determined using X-ray diffraction analysis. The lattice parameters, the cell volume and phase composition of prepared powders were determined by Rietveld refinement using software DIFFRAC.SUITE TOPAS V.5.0. The precipitated powders were composed of HAp, OCP and amorphous CaP. After heat treatment, crystalline phase of β-TCP was detected. The chemical composition of unsubstituted and Sr-substituted HAp/OCP powders were determined by inductively coupled plasma mass spectrometry.

hydroxyapatite, calcium phosphate, strontium, ion substitution

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