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izvor podataka: crosbi

Histological and MRI study of the development of the human indusium griseum (CROSBI ID 263400)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Bobić Rasonja, Mihaela ; Orešković, Darko ; Knezović, Vinka ; Pogledić, Ivana ; Pupačić, Daniela ; Vukšić, Mario ; Brugger, Peter C ; Prayer, Daniela ; Petanjek, Zdravko ; Jovanov Milošević, Nataša Histological and MRI study of the development of the human indusium griseum // Cerebral cortex, 29 (2019), 11; 4709-4724. doi: 10.1093/cercor/bhz004

Podaci o odgovornosti

Bobić Rasonja, Mihaela ; Orešković, Darko ; Knezović, Vinka ; Pogledić, Ivana ; Pupačić, Daniela ; Vukšić, Mario ; Brugger, Peter C ; Prayer, Daniela ; Petanjek, Zdravko ; Jovanov Milošević, Nataša

engleski

Histological and MRI study of the development of the human indusium griseum

To uncover the ontogenesis of the human indusium griseum (IG), 28 post-mortem fetal human brains, 12–40 postconceptional weeks (PCW) of age, and 4 adult brains were analyzed immunohistochemically and compared with post- mortem magnetic resonance imaging (MRI) of 28 fetal brains (14– 41 PCW). The morphogenesis of the IG occurred between 12 and 15 PCW, transforming the bilateral IG primordia into a ribbon-like cortical lamina. The histogenetic transition of sub-laminated zones into the three- layered cortical organization occurred between 15 and 35 PCW, concomitantly with rapid cell differentiation that occurred from 18 to 28 PCWand the elaboration of neuronal connectivity during the entire second half of gestation. The increasing number of total cells and neurons in the IG at 25 and 35 PCWconfirmed its continued differentiation throughout this period. High-field 3.0 T post-mortem MRI enabled visualization of the IG at the mid- fetal stage using T2-weighted sequences. In conclusion, the IG had a distinct histogenetic differentiation pattern than that of the neighboring intralimbic areas of the same ontogenetic origin, and did not show any signs of regression during the fetal period or postnatally, implying a functional role of the IG in the adult brain, which is yet to be disclosed.

corpus callosum ; fetal brain ; hippocampus ; immunohistochemistry ; magnetic resonance imaging

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Podaci o izdanju

29 (11)

2019.

4709-4724

objavljeno

1047-3211

1460-2199

10.1093/cercor/bhz004

Povezanost rada

Temeljne medicinske znanosti

Poveznice
Indeksiranost