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Synthesis, characterization and cytotoxicity of dioxomolybdenum(VI) complexes with 4-methoxysalicylaldehyde isonicotinoyl hydrazone

Hydrazones, versatile ligands with the C=N–N group, and their metal complexes have been in the focus of interest due to applications in various fields, e.g. analytical chemistry, catalysis, pharmacy [1, 2]. In addition, these types of compounds have diverse biological activities such as cytotoxic activity [3]. However, literature reports on the in vitro cytotoxic activity of dioxomolybdenum(VI) complexes with hydrazones are very rare [4]. In this work, dioxomolybdenum(VI) complexes with 4‐methoxysalicylaldehyde isonicotinoyl hydrazone (H2L) were synthesized by the reaction of [MoO2(acac)2] and H2L with the addition of acid (HCl, HBr, HNO3 or H2SO4). The obtained [MoO2(HL)(MeOH)]X (X = Cl, Br, NO3, HSO4) compounds were characterized by elemental and thermogravimetric analysis, IR and NMR spectroscopy, and X‐ray diffraction methods (PXRD and SCXRD when suitable). The in vitro cytotoxicity of these compounds was investigated on human acute monocytic leukemia (THP‐1) and hepatocellular carcinoma (HepG2) cell lines. Each cell line was treated with various concentrations of the tested compounds and the viability of cells after treatment was determined using MTS assay. IC50 values were calculated for all tested compounds from dose‐ response curves. In [MoO2(HL)(MeOH)]+, the aroylhydrazone is coordinated to {; ; ; ; ; MoO2}; ; ; ; ; 2+ core through the O, N, O donor atoms (Figure 1). All compounds exhibited no cytotoxic activity on HepG2, whereas substantial cytotoxicity on THP‐1 cells was observed. Molybdenum(VI) compounds exhibited greater cytotoxicity than the free hydrazone.

hydrazone ; dioxomolybdenum(VI) complexes ; cytotoxicity

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