Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes (CROSBI ID 264262)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Trajković, Katarina ; Hsu, Chieh ; Chiantia, Salvatore ; Rajendran, Lawrence ; Wenzel, Dirk ; Wieland, Felix ; Schwille, Petra ; Brugger, Britta ; Simons, Mikael Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes // Science, 319 (2008), 5867; 1244-1247. doi: 10.1126/science.1153124

Podaci o odgovornosti

Trajković, Katarina ; Hsu, Chieh ; Chiantia, Salvatore ; Rajendran, Lawrence ; Wenzel, Dirk ; Wieland, Felix ; Schwille, Petra ; Brugger, Britta ; Simons, Mikael

engleski

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

Intraluminal vesicles of multivesicular endosomes are either sorted for cargo degradation into lysosomes or secreted as exosomes into the extracellular milieu. The mechanisms underlying the sorting of membrane into the different populations of intraluminal vesicles are unknown. Here, we find that cargo is segregated into distinct subdomains on the endosomal membrane and that the transfer of exosome-associated domains into the lumen of the endosome did not depend on the function of the ESCRT (endosomal sorting complex required for transport) machinery, but required the sphingolipid ceramide. Purified exosomes were enriched in ceramide, and the release of exosomes was reduced after the inhibition of neutral sphingomyelinases. These results establish a pathway in intraendosomal membrane transport and exosome formation.

exosome ; ceramide

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

319 (5867)

2008.

1244-1247

objavljeno

0036-8075

1095-9203

10.1126/science.1153124

Povezanost rada

Biologija

Poveznice
Indeksiranost