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Serum Concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are Associated with Increased 3-Month Mortality in Acute Heart Failure Patients (CROSBI ID 264312)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Stryeck, Sarah ; Gastrager, Michaela ; Degoricija, Vesna ; Trbušić, Matias ; Potočnjak, Ines ; Radulović, Bojana ; Pregartner, Gudrun ; Berghold, Andrea ; Madl, Tobias ; Frank, Saša Serum Concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are Associated with Increased 3-Month Mortality in Acute Heart Failure Patients // Scientific reports, 2019 (2019), 9; 6743-6743. doi: 10.1038/s41598-019-42937-w

Podaci o odgovornosti

Stryeck, Sarah ; Gastrager, Michaela ; Degoricija, Vesna ; Trbušić, Matias ; Potočnjak, Ines ; Radulović, Bojana ; Pregartner, Gudrun ; Berghold, Andrea ; Madl, Tobias ; Frank, Saša

engleski

Serum Concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are Associated with Increased 3-Month Mortality in Acute Heart Failure Patients

Considering the already established relationship between the extent of the metabolic dysfunction and the severity of heart failure (HF), it is conceivable that the metabolomic profile of the serum may have a prognostic capacity for 3-month mortality in acute heart failure (AHF). Out of 152 recruited patients, 130 serum samples were subjected to the metabolomic analyses. The 3-month mortality rate was 24.6% (32 patients). Metabolomic profiling by nuclear magnetic resonance spectroscopy found that the serum levels of 2- hydroxybutyrate (2-HB), 3-hydoxybutyrate (3- HB), lactate, citrate, and tyrosine, were higher in patients who died within 3 months compared to those who were alive 3 months after onset of AHF, which was confirmed by univariable logistic regression analyses (p = 0.009, p = 0.005, p = 0.008, p<0.001, and p<0.001, respectively). These associations still remained significant for all tested metabolites except for lactate after adjusting for established prognostic parameters in HF. In conclusion, serum levels of 2-HB, 3-HB, tyrosine, and citrate measured at admission are associated with an increased 3-month mortality rate in AHF patients and might thus be of prognostic value in AHF.

Citrate ; Tyrosine ; 2- and 3- Hydroxybutirate ; Mortality rate ; Heart failure

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nije evidentirano

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Podaci o izdanju

2019 (9)

2019.

6743-6743

objavljeno

2045-2322

10.1038/s41598-019-42937-w

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti

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