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Application of CellDesigner program for nutrition planning and food safety control (CROSBI ID 675852)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Marić, Lucija ; Malešić, Elena ; Šanko, Katarina ; Jurina, Tamara ; Valinger, Davor ; Gajdoš Kljusurić, Jasenka ; Benković, Maja ; Jurinjak Tušek, Ana Application of CellDesigner program for nutrition planning and food safety control // Sixth International Conference Sustainable Postharvest and Food Technologies INOPTEP 2019 Book of Abstracts / Babić, Mirko ; Pavkov, Ivan ; Radojčin, Milivoj (ur.). Novi Sad: National Society of Processing and Energy in Agriculture, Novi Sad, Serbia, 2019. str. 109-109

Podaci o odgovornosti

Marić, Lucija ; Malešić, Elena ; Šanko, Katarina ; Jurina, Tamara ; Valinger, Davor ; Gajdoš Kljusurić, Jasenka ; Benković, Maja ; Jurinjak Tušek, Ana

engleski

Application of CellDesigner program for nutrition planning and food safety control

Despite of their high potential, computational modelling and simulation techniques are still marginally used in nutritional science. Taking into account that practically all cellular processes can be affected by diet and lifestyle and that nutrients and non-nutrient components of food alter the metabolic functions of the cell in complex ways, the usage of computational tool for understanding the role of nutritional compounds on the cell is mandatory. Over the years numerous researchers demonstrated that public heath nutritional recommendations are not suitable for precise nutrition planning and that personalized nutrition should be adopted. Personalized nutrition designs the nutrition plan based on specific biological requirements of the individual taking into account its health status. To explain the interconnections between nutrition and health status multiple biological process occurring in various tissues should be included, which is impossible without the use of computational modelling tools. In this work the application of CellDesigner 4.0 (Systems Biology Institute (SBI), Tokyo, Japan) for nutrition planning and food safety control was tested through three models: (i) model of the glycolysis metabolism, (ii) folate-mediated 1-carbon metabolism and (iii) arsenic metabolism in the liver. Each model was simulated with different initial nutrient concentrations and with different enzymes activities. After model design and simulations in CellDesigner, it can be concluded that the use of computational tools allows fast and reproducible analysis of different input concentrations and the effect of different enzyme activity on specific metabolic process in human organisms. Application of computational modelling for nutrient based pathway ensures detail insight in metabolic process and simple control of the metabolic reaction influenced by nutrient intake. It also presents the changes based on the cell load, giving an insight to what is happening and why in a situations where a certain nutrient is dominant. Computational approach also simplifies prediction of potential hazards in foods.

CellDesigner ; mathematical modelling ; nutrition planning ; food safety

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Podaci o prilogu

109-109.

2019.

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objavljeno

978-86-7520-458-9

Podaci o matičnoj publikaciji

Sixth International Conference Sustainable Postharvest and Food Technologies INOPTEP 2019 Book of Abstracts

Babić, Mirko ; Pavkov, Ivan ; Radojčin, Milivoj

Novi Sad: National Society of Processing and Energy in Agriculture, Novi Sad, Serbia

Podaci o skupu

6th International Conference Sustainable postharvest and food technologies (INOPTEP 2019) ; 31st National Conference Prosessing and Energy in Agriculture (PTEP 2019)

poster

07.04.2019-12.04.2019

Kladovo, Srbija

Povezanost rada

Prehrambena tehnologija, Nutricionizam, Interdisciplinarne biotehničke znanosti