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Bibliographic record number: 913432

Journal

Authors: Mihailović-Stanojević, Nevena; Miloradović, Zoran; Ivanov, Milan; Bugarski, Branko; Jovović, Đurđica; Karanović, Danijela; Vajić, Una-Jovana; Komes, Draženka; Grujić-Milanović, Jelica
Title: Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress
Source: Oxidative medicine and cellular longevity (1942-0900) 2016 (2016);
Paper type: article
Keywords: Blood pressure ; Lipid peroxides ; Rats, Antioxidant ; Polyphenols ; Induction ; Tissues ; Herbs
Abstract:
High blood pressure is the most powerful contributor to the cardiovascular morbidity and mortality, and inverse correlation between consumption of polyphenol-rich foods or beverages and incidence of cardiovascular diseases gains more importance. Reactive oxygen species plays an important role in the development of hypertension. We found that wild thyme (a spice plant, rich in polyphenolic compounds) induced a significant decrease of blood pressure and vascular resistance in hypertensive rats. The inverse correlation between vascular resistance and plasma heme oxygenase-1 suggests that endogenous vasodilator carbon monoxide generated by heme oxidation could account for this normalization of blood pressure. Next product of heme oxidation, bilirubin (a chain-breaking antioxidant that acts as a lipid peroxyl radical scavenger), becomes significantly increased after wild thyme treatment and induces the reduction of plasma lipid peroxidation in hypertensive, but not in normotensive rats. The obtained results promote wild thyme as useful supplement for cardiovascular interventions.
Original language: ENG
Citation databases: MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Category: Znanstveni
Research fields:
Biology,Food processing technology
URL: https://www.hindawi.com/journals/omcl/2016/1458793/
http://dx.doi.org/10.1155/2016/1458793
Broj citata:
Altmetric:
DOI: 10.1155/2016/1458793
URL cjelovitog rada:
Google Scholar: Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress
Contrib. to CROSBI by: Sara Karača (skaraca@pbf.hr), 18. Pro. 2017. u 13:56 sati



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