Multiple sclerosis and lichen planus are not uncommonly observed in isolation, but rarely in combination, because they are clinically and histologically distinct complex disorders of putative autoimmune etiology. Only two previous reports have described cutaneous lichen planus in association with multiple sclerosis. In this study, we describe a 51-year old Caucasian woman that exhibited both familial multiple sclerosis and lichen ruber planus. This combination could have occurred by chance, or it might imply that these diseases share common mechanisms in their pathogenesis.