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Pregled bibliografske jedinice broj: 105757

Zbornik radova

Autori: Lazić, Ratimir; Gabrić, Nikica; Dekaris, Iva; Karaman-Martinović, Željka; Mravičić, Ivana; Boban-Blagaić, Alenka; Sikirić, Predrag
Naslov: Pentapeptide BPC 157 and its role in corneal epithelial wounds healing in rats
( Pentapeptide BPC 157 and its role in corneal epithelial wounds healing in rats )
Izvornik: 25th International Congress of Ophthalmology Alpe-Adria Community : Abstract book
Skup: International Congress of Ophthalmology Alpe-Adria Community (25 ; 20019
Mjesto i datum: Ljubljana, Slovenija, 12-13.10.2001.
Ključne riječi: pentapeptide BPC 157; wound healing; cornea; rats; epitelial defects
( pentapeptide BPC 157; wound healing; cornea; rats )
Sažetak:
Purpose. To evaluate the role of BPC 157 in corneal epithelial wounds healing in rats. Methods. 92 albino Wistar rats, 200 g b.w. were divided in 4 groups ( A, B, C, D ) each containing 23 animals. After intraperitoneal and topical anesthesia, circular lesions were induced to the right eye by abrading corneal epithelium with surgical lancet under surgical microscope leaving 1 mm of non-abraded epithelial ring adjacent to the limbus. Wounds were stained with standard florescein and photographed. Immediately after wounds were induced and photographed, the animals were administered eye drops as follows: group A (control group) - 0.9 % NaCl (2 drops), group B - BPC 157 2pg/ml dissolved in 0.9% NaCl (2 drops), group C- BPC 157 2 ng/ml in 0.9% NaCl (2 drops), group D-BPC 157 2µ ; g in 0.9% NaCl (2 drops). Drops were applied during a 24 h period at 0 h, 8 h, 16 h, 24 h. Lesions were stained and photographed every 8 hours: at 0 hours (induction), 8 h, 16 h, 24 h and 32 h after induction prior to treatment. The pictures were analyzed using VAMS , an image analysis system. The size of the epithelial wound area at a particular time (8, 16, 24, 32 h) was shown as a percentage of the wound area size at time 0h (100 % -the basic starting value) for every animal in every group. Data was then compared between groups to see whether there was a difference in healing area size. Results. Quite extensive lesions were induced in all rats before therapy initiation. Even at the earliest assessment point 8 hours after injury was induced, lesions became smaller, in all groups. When compared to the control group lesions were significantly smaller in groups C and D. Also assessed at later intervals at 16 h, 24 h and 32 h after injury was induced, lesions were significantly smaller in pentadecapeptide BPC 157 rats treated with µ ; g and ng solutions (groups C and D). Conclusion. BPC 157 was shown to be effective in promoting corneal wounds healing in rats. The results were dose dependent.
Vrsta sudjelovanja: Predavanje
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 129007, 0129010, 0129007
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Napomene:
Rad je kao predavanje prezentiran i na skupu International Symposium on ocular immunology, inflamation & transplantation, održanom od 22.-24.09.2002., London, Velika Britanija, objavljen u Knjizi sažetaka, str. 32-32 ; a kao poster na skupu ARVO Annual Meeting, održanom od 04.-09.05.2003., Fort Lauderdale, Florida, SAD, također objavljen u Knjizi sazetaka, str. 158-158.



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