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Pregled bibliografske jedinice broj: 108216

Časopis

Autori: Herak-Perković, Vlasta; Grabarević, Željko; Banić, Marko; Anić, Branimir; Novosel, Vesna; Pogačnik, Milan
Naslov: Effects of dopaminergic drugs on inflammatory bowel disease induced with 2, 4- dinitrofluorbenzene in BALB/c mice
( Effects of dopaminergic drugs on inflammatory bowel disease induced with 2, 4-dinitrofluorbenzene in BALB/c mice )
Izvornik: Journal of veterinary pharmacology and therapeutics (0140-7783) 24 (2001), 4; 267-273
Vrsta rada: članak
Ključne riječi: induced gastric-ulcers ; therapeutic applications ; animal-model ; agonists ; rats ; stomach ; bromocriptine
( induced gastric-ulcers ; therapeutic applications ; animal-model ; agonists ; rats ; stomach ; bromocriptine )
Sažetak:
The aim of the study was to demonstrate the effects of dopaminergic drugs on 2, 4- dinitrofluorbenzene (DNFB) induced experimental inflammatory bowel disease (IBD) in previously sensitised BALB/c mice. The number and extent of ulcerations and erosions, the intensity of haeomorrhages, edema, and accumulation of neutrophils and eosinophils within colonic lamina propria and submucosa were scored and statistically evaluated. The 180 BALB/c mice, were allocated into three equal groups. The mice in the first experimental group were treated with domperidone (DP), a peripheral dopamine (DA) antagonist. The mice from the second experimental group were treated with bromocriptine (BC), a dopamine agonist. The mice from the control group were treated with an equivalent volume of normal saline in the same manner. Ten animals from each group were killed on days 1, 2, 3, 5, and 10, subsequent to the challenge enema of the DNFB solution. Gross and microscopic examination of the colon was performed. Treatment with BC resulted in clinical improvement and decreased mortality rate by 2 of 60 (3%), while domperidone treatment increased mortality rate to 12 of 60 (20%) compared with the controls (4 of 60 /6%/). The nalysis of the microscopic lesions indicated that the beneficial effects of BC were the result of maintenance of vascular integrity.
Projekt / tema: 053019
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Veterinarska medicina
URL Internet adrese: http://www.blackwell-synergy.com/doi/abs/10.1046/j.1365-2885.2001.00343.x
Broj citata:
Altmetric:
DOI: 10.1046/j.1365-2885.2001.00343.x
URL cjelovitog teksta:
Google Scholar: Effects of dopaminergic drugs on inflammatory bowel disease induced with 2, 4- dinitrofluorbenzene in BALB/c mice



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